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Article

Wnt target gene activation requires β-catenin separation into biomolecular condensates.

PLoS biology - 1 Sept 2024

Stewart Richard A, Ding Zhihao, Jeon Ung Seop, Goodman Lauren B, Tran Jeannine J, Zientko John P, Sabu Malavika, Cadigan Ken M

Abstract excerpt

The Wnt/β-catenin signaling pathway plays numerous essential roles in animal development and tissue/stem cell maintenance. The activation of genes regulated by Wnt/β-catenin signaling requires the nuclear accumulation of β-catenin, a transcriptional co-activator. β-catenin is recruited to many Wnt-regulated enhancers through direct binding to T-cell factor/lymphoid enhancer factor (TCF/LEF) family transcription...

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PMID: 39316611
DOI: 10.1371/journal.pbio.3002368
PMCID: PMC11460698

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