Article
Dual-role transcription factors stabilize intermediate expression levels.
Cell - 23 May 2024
He Jinnan, Huo Xiangru, Pei Gaofeng, Jia Zeran, Yan Yiming, Yu Jiawei, Qu Haozhi, Xie Yunxin, Yuan Junsong, Zheng Yuan, Hu Yanyan, Shi Minglei, You Kaiqiang, Li Tingting, Ma Tianhua, Zhang Michael Q, Ding Sheng, Li Pilong, Li Yinqing
Abstract excerpt
Precise control of gene expression levels is essential for normal cell functions, yet how they are defined and tightly maintained, particularly at intermediate levels, remains elusive. Here, using a series of newly developed sequencing, imaging, and functional assays, we uncover a class of transcription factors with dual roles as activators and repressors, referred to as condensate-forming level-regulating...
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