Article

RNA binding is essential for NONO condensates to modulate pre-mRNA processing of super enhancer-associated genes in neuroblastoma

2022-02-28

Abstract excerpt

High-risk neuroblastoma patients have poor survival rates and require better therapeutic options. High expression of a multifunctional DNA and RNA binding protein, NONO, in neuroblastoma is associated with poor patient outcome, however there is little understanding of the mechanism of NONO-dependent oncogenic gene regulatory activity in neuroblastoma. Here, we used cell imaging, biophysical and molecular analysis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: abf5ab68-2293-5e3a-b983-37eb796335bf
DOI: 10.1101/2022.02.28.482217

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA binding is essential for NONO condensates to modulate pre-mRNA processing of super enhancer-associated genes in neuroblastomaDOI 10.1101/2022.02.28.482217Read

Saying “Yes” to NONO: A Target for Neuroblastoma Therapy?Semantic proximity Read

NONO as a Sensor of Intracellular Oxidation: Relevance to Neuroblastoma Cell DeathSemantic proximity Read

Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer loopingSemantic proximity Read

Biomolecular condensates of Eya drive transcriptional co-activation associated with eye developmentSemantic proximity Read

Paraspeckle Protein NONO Regulates Active Chromatin by Allosterically Stimulating NSD1Semantic proximity Read

Super enhancers define regulatory subtypes and cell identity in neuroblastoma.Semantic proximity Read

Phase separation of Myc differentially modulates the transcriptomeSemantic proximity Read

Chromatin-enriched RNAs mark active and repressive cis-regulation: an analysis of nuclear RNA-seqSemantic proximity Read

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesisSemantic proximity Read

Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcriptsSemantic proximity Read

Stable interaction of NONO with DBHS family members upon etoposide-induced DNA damageSemantic proximity Read

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule CompoundsSemantic proximity Read