Article

MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation

2025-08-11

Abstract excerpt

MORC2 is a chromatin-associated ATPase essential for transcriptional silencing and genome stability, yet the biophysical principles governing its regulatory activity remain elusive. Here, we demonstrate that full-length MORC2 undergoes biomolecular condensation to form dynamic nuclear assemblies, a process fundamentally required for its repressor function. Endogenous MORC2 forms discrete, dynamic condensates in ne...

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Literature Corpus work: 71ec4830-90f6-5219-b54e-a234d0c5563c
DOI: 10.1101/2025.08.08.669439

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