Article
Enhancer hubs and loop collisions identified from single-allele topologies.
Nature genetics - 1 Aug 2018
Allahyar Amin, Vermeulen Carlo, Bouwman Britta A M, Krijger Peter H L, Verstegen Marjon J A M, Geeven Geert, van Kranenburg Melissa, Pieterse Mark, Straver Roy, Haarhuis Judith H I, Jalink Kees, Teunissen Hans, Renkens Ivo J, Kloosterman Wigard P, Rowland Benjamin D, de Wit Elzo, de Ridder Jeroen, de Laat Wouter
Abstract excerpt
Chromatin folding contributes to the regulation of genomic processes such as gene activity. Existing conformation capture methods characterize genome topology through analysis of pairwise chromatin contacts in populations of cells but cannot discern whether individual interactions occur simultaneously or competitively. Here we present multi-contact 4C (MC-4C), which applies Nanopore sequencing to study multi-way...
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