Article

Multi-scale phase separation by explosive percolation with single chromatin loop resolution

2022-04-29

Abstract excerpt

The 2m-long human DNA is tightly intertwined into the cell nucleus of the size of 10μm. The DNA packing is explained by folding of chromatin fiber. This folding leads to the formation of such hierarchical structures as: chromosomal territories, compartments; densely packed genomic regions known as Chromatin Contact Domains (CCDs), and loops. We propose models of dynamical genome folding into hierarchical component...

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Literature Corpus work: 641da425-602c-5f8a-8dfd-fe78ca46ccd7
DOI: 10.1101/2022.04.28.489670

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