Article

Human polymerase theta helicase positions DNA microhomologies for double-strand break repair

2024-04-27

Abstract excerpt

DNA double-strand breaks occur in all human cells on a daily basis and must be repaired with high fidelity to minimize genomic instability 1 . Deficiencies in high-fidelity DNA repair by homologous recombination lead to dependence on DNA polymerase theta, which identifies DNA microhomologies in 3’ single-stranded DNA overhangs and anneals them to initiate error-prone double-strand break repair. The resulting geno...

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Literature Corpus work: e1d5ae34-c842-5160-b014-5d051218b559
DOI: 10.1101/2024.04.26.591388

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