Article

Mechanistic Basis for Microhomology Identification and Genome Scarring by Polymerase Theta

2019-12-20

Abstract excerpt

DNA Polymerase Theta mediates an end joining pathway (TMEJ) that repairs chromosome breaks. It requires resection of broken ends to generate long, 3’ single stranded DNA tails, annealing of complementary sequence segments (microhomologies) in these tails, followed by microhomology-primed synthesis sufficient to resolve broken ends. The means by which microhomologies are identified is thus a critical step in this p...

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Literature Corpus work: 21958f54-4d54-57cd-be57-7f1db3aaf198
DOI: 10.1101/2019.12.20.882852

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