The cryo-electron microscopy structure of human transcription factor IIH.

Abstract excerpt

Human transcription factor IIH (TFIIH) is part of the general transcriptional machinery required by RNA polymerase II for the initiation of eukaryotic gene transcription. Composed of ten subunits that add up to a molecular mass of about 500 kDa, TFIIH is also essential for nucleotide excision repair. The seven-subunit TFIIH core complex formed by XPB, XPD, p62, p52, p44, p34, and p8 is competent for DNA repair,...

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• Adenosine Triphosphatases
• Adenosine Triphosphate
• Cryoelectron Microscopy
• Models, Molecular
• Mutation