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Article

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.

Molecular cell - 18 Aug 2016

Wyatt David W, Feng Wanjuan, Conlin Michael P, Yousefzadeh Matthew J, Roberts Steven A, Mieczkowski Piotr, Wood Richard D, Gupta Gaorav P, Ramsden Dale A

Abstract excerpt

DNA polymerase theta (Pol θ)-mediated end joining (TMEJ) has been implicated in the repair of chromosome breaks, but its cellular mechanism and role relative to canonical repair pathways are poorly understood. We show that it accounts for most repairs associated with microhomologies and is made efficient by coupling a microhomology search to removal of non-homologous tails and microhomology-primed synthesis...

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Source

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Identifiers

PMID: 27453047
DOI: 10.1016/j.molcel.2016.06.020
PMCID: PMC4992412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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