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Article

Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.

Nature communications - 8 Dec 2021

Kamp J A, Lemmens B B L G, Romeijn R J, Changoer S C, van Schendel R, Tijsterman M

Abstract excerpt

DNA double-strand breaks are a major threat to cellular survival and genetic integrity. In addition to high fidelity repair, three intrinsically mutagenic DNA break repair routes have been described, i.e. single-strand annealing (SSA), polymerase theta-mediated end-joining (TMEJ) and residual ill-defined microhomology-mediated end-joining (MMEJ) activity. Here, we identify C. elegans Helicase Q (HELQ-1) as being...

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Source

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Identifiers

PMID: 34880204
DOI: 10.1038/s41467-021-27408-z
PMCID: PMC8654963

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