Article

APOBEC3A-Induced DNA Damage Drives Polymerase θ Dependency and Synthetic Lethality in Cancer

2025-10-22

Abstract excerpt

APOBEC3 cytidine deaminases drive cancer evolution. There is an unmet need to target cancer cells with APOBEC3 activity. Here, we identify error-prone theta-mediated end joining (TMEJ) as the main pathway for repairing APOBEC3-induced double-strand breaks (DSBs). Using fluorescent DSB repair reporters and a novel biochemical assay, we demonstrate that APOBEC3A competes with replication protein A (RPA) for single-s...

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Identifiers and source

Literature Corpus work: 03afdaab-2853-5d7a-a6d0-84aae5e50edc
DOI: 10.1101/2025.10.21.682588

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