Article

Cryo-EM structures of human RNA polymerase I

2021-06-01

Abstract excerpt

RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here, we report the cryo-EM structure of elongating human Pol I at 2.7 Å resolution. In the exit tunnel, we observe a double-stranded RNA helix that may support Pol I processivity. Our structure confirms that human Pol I consists of 13 subu...

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Literature Corpus work: 58507451-c1ea-508b-8e2d-2b38d7ffc447
DOI: 10.1101/2021.05.31.446457

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