Article

Structural basis of TFIIH activation for nucleotide excision repair

2019-05-07

Abstract excerpt

Genomes are constantly threatened by DNA damage, but cells can remove a large variety of DNA lesions by nucleotide excision repair (NER) 1 . Mutations in NER factors compromise cellular fitness and cause human diseases such as Xeroderma pigmentosum (XP), Cockayne syndrome and trichothiodystrophy 2,3 . The NER machinery is built around the multisubunit transcription factor IIH (TFIIH), which opens the DNA repair...

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Literature Corpus work: 5047aeda-5569-525c-97c9-47ddc7c172a7
DOI: 10.1101/628032

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