Article

The human RNA polymerase I structure reveals an HMG-like transcription factor docking domain specific to metazoans

2021-12-22

Abstract excerpt

Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant of cellular growth and dysregulation is observed in many cancer types. Here, we present the purification of human Pol I from cells carrying a genomic GFP-fusion on the largest subunit allowing the structural and functional analysis of the enzyme across species. In contrast to yeast, human Pol I carries a single-subunit st...

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Literature Corpus work: e79f460a-f494-555d-8c05-f57d784be146
DOI: 10.1101/2021.12.22.473891

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