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Article

Structure of human telomerase holoenzyme with bound telomeric DNA.

Nature - 1 May 2021

Ghanim George E, Fountain Adam J, van Roon Anne-Marie M, Rangan Ramya, Das Rhiju, Collins Kathleen, Nguyen Thi Hoang Duong

Abstract excerpt

Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere loss that is caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, and mutations that compromise the function of telomerase result in disease2. A previous structure of human telomerase at a resolution of 8 Å revealed a vertebrate-specific composition and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33883742
DOI: 10.1038/s41586-021-03415-4
PMCID: PMC7610991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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