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Somatic mutations reveal the ontogeny of human microglia

2026-05-20

Abstract excerpt

Microglia are the resident hematopoietic cells of the central nervous system 1 . In mice, microglia seed the brain during embryogenesis and can be maintained throughout life with minimal input from adult hematopoiesis 2–4 . The origins of human microglia are less clear, but recent evidence suggests that marrow-derived cells may be able to supplement the human microglial pool in certain individuals 5,6 . Here, t...

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Literature Corpus work
e1a976a5-843b-531c-b856-69ca61103cba
DOI
10.64898/2026.05.19.726366
Open publication

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