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Article

A myeloid trisomy 21-associated gene variant is protective from Alzheimer's disease.

Nature neuroscience - 1 Jan 2026

Jin Mengmeng, Ma Ziyuan, Dang Rui, Zhang Haiwei, Kim Rachael, Xue Haipeng, Pascual Jesse, Yu Hanwen, Papetti Ava V, Liu Yan, Finkbeiner Steven, Head Elizabeth, Liu Ying, Jiang Peng

Abstract excerpt

Alzheimer's disease causes progressive cognitive decline, yet some individuals remain resilient despite developing hallmark pathology. A subset of people with Down syndrome (DS), the most common genetic cause of Alzheimer's disease, demonstrates such resilience. Given the elevated risk of hematopoietic mutations in DS, we hypothesize that certain variants may confer microglial resilience. Here, we introduce a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41286452
DOI: 10.1038/s41593-025-02117-8
PMCID: PMC13003559

Genes

CSF2RB

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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