Article

Clonal hematopoiesis is associated with protection from Alzheimer’s disease

2021-12-13

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a pre-malignant expansion of mutated blood stem cells that also associates with non-hematological disorders. Here, we tested whether CHIP was associated with Alzheimer’s disease (AD). Surprisingly, we found that CHIP carriers had reduced risk of AD dementia or AD neuropathologic features in multiple cohorts. The same mutations found in blood were also detec...

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Literature Corpus work: 06a07f0e-a5fe-5176-8bec-9664c9e81b9d
DOI: 10.1101/2021.12.10.21267552

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