Article

Mosaic loss of chromosome Y in aged human microglia

2021-11-20

Abstract excerpt

Mosaic loss of chromosome Y (LOY) is a particularly common acquired structural mutation in the leukocytes of aging men and it has been shown to correlate with several age-related diseases including Alzheimer’s disease (AD). To derive the molecular basis of LOY in brain cells, we create an integrated resource by aggregating data from 21 single-cell and single-nuclei RNA brain studies, yielding 763,410 cells to inve...

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Literature Corpus work: 6d574f69-5bf8-569e-af2b-0ee786173229
DOI: 10.1101/2021.11.19.469312

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