Article
A microglia clonal inflammatory disorder in Alzheimer's disease.
eLife - 14 Mar 2025
Vicario Rocio, Fragkogianni Stamatina, Weber Leslie, Lazarov Tomi, Hu Yang, Hayashi Samantha Y, Craddock Barbara, Socci Nicholas D, Alberdi Araitz, Baako Ann, Ay Oyku, Ogishi Masato, Lopez-Rodrigo Estibaliz, Kappagantula Rajya, Viale Agnes, Iacobuzio-Donahue Christine A, Zhou Ting, Ransohoff Richard M, Chesworth Richard, Abdel-Wahab Omar, Boisson Bertrand, Elemento Olivier, Casanova Jean-Laurent, Miller W Todd, Geissmann Frédéric
Abstract excerpt
Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer's disease (AD). Here, we report the selective enrichment of microglia clones carrying pathogenic variants, that are not present in neuronal, glia/stromal cells, or blood, from patients with AD...
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