Article
A microglia clonal inflammatory disorder in Alzheimer’s Disease
2024-01-25
Abstract excerpt
<h4>Summary</h4> Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however few studies have investigated its role in neurodegenerative processes such as Alzheimer’s Disease (AD). Here we report the selective enrichment of microglia clones carrying pathogenic variants, that are not present in neuronal, glia/stromal cells, or blood, from p...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 206e6d61-a9c8-5f8a-af8c-3f531bd77034
- DOI
- 10.1101/2024.01.25.577216