Article

Monocyte-derived microglia with <i>Dnmt3a</i> mutation cause motor pathology in aging mice

2023-11-17

Abstract excerpt

Microglia are established in embryogenesis forming a self-containing cellular compartment resisting seeding with cells derived from adult definitive hematopoiesis. We report that monocyte-derived macrophages (MoMΦ) accumulate in the brain of aging mice with distinct topology, including the nigrostriatum and medulla, but not the frontal cortex. Parenchymal MoMΦ adopt bona fide microglia expression profiles. Unlike...

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Literature Corpus work: e7144c59-54f1-52d6-a654-27608062eb16
DOI: 10.1101/2023.11.16.567402

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