Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program.

doi:10.1016/j.cell.2019.11.010

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Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program.

Cell - 12 Dec 2019

Geirsdottir Laufey, David Eyal, Keren-Shaul Hadas, Weiner Assaf, Bohlen Stefan Cornelius, Neuber Jana, Balic Adam, Giladi Amir, Sheban Fadi, Dutertre Charles-Antoine, Pfeifle Christine, Peri Francesca, Raffo-Romero Antonella, Vizioli Jacopo, Matiasek Kaspar, Scheiwe Christian, Meckel Stephan, Mätz-Rensing Kerstin, van der Meer Franziska, Thormodsson Finnbogi Rutur, Stadelmann Christine, Zilkha Noga, Kimchi Tali, Ginhoux Florent, Ulitsky Igor, Erny Daniel, Amit Ido, Prinz Marco

Abstract excerpt

Microglia, the brain-resident immune cells, are critically involved in many physiological and pathological brain processes, including neurodegeneration. Here we characterize microglia morphology and transcriptional programs across ten species spanning more than 450 million years of evolution. We find that microglia express a conserved core gene program of orthologous genes from rodents to humans, including...

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PMID: 31835035
DOI: 10.1016/j.cell.2019.11.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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