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Article

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

2024-01-04

Abstract excerpt

<h4>Summary</h4> Alzheimer’s disease (AD) is an age-associated neurodegenerative disorder characterized by progressive neuronal loss and pathological accumulation of the misfolded proteins amyloid-β and tau 1,2 . Neuroinflammation mediated by microglia and brain-resident macrophages plays a crucial role in AD pathogenesis 1–5 , though the mechanisms by which age, genes, and other risk factors interact remain la...

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Literature Corpus work
36c880cd-9333-5322-b529-41e5664e38a0
DOI
10.1101/2024.01.03.574078
Open publication

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