Article

Mapping targetable sites on the human surfaceome for the design of novel binders

2024-12-16

Abstract excerpt

The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo protein binder design against these cell surface proteins offers a promising yet underexplored strategy for drug development. However, the vast search space and limited data on natural or competitive binders have historically limited experimental success. In this study, w...

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Identifiers and source

Literature Corpus work: e1a062de-82ce-518e-bf64-452897980573
DOI: 10.1101/2024.12.16.628626

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