Article

DirectContacts2: A network of direct physical protein interactions derived from high-throughput mass spectrometry experiments

2025-07-22

Abstract excerpt

Cellular function is driven by the activity proteins in stable complexes. Protein complex assembly depends on the direct physical association of component proteins. Advances in macromolecular structure prediction with tools like AlphaFold and RoseTTAFold have greatly improved our ability to model these interactions in silico, but an all-by-all analysis of the human proteome’s ~200M possible pairs remains computat...

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Literature Corpus work: 3d75013e-1139-5266-9215-4c2ea5afd619
DOI: 10.1101/2025.07.17.665435

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