Article

<i>De novo</i> design of phosphotyrosine peptide binders

2025-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Phosphorylation on tyrosine is a key step in many signaling pathways. Despite recent progress in de novo design of protein binders, there are no current methods for designing binders that recognize phosphorylated proteins and peptides; this is a challenging problem as phosphate groups are highly charged, and phosphorylation often occurs within unstructured regions. Here we introduce RoseTTAFold...

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Literature Corpus work: 1a04e3d1-a145-54b4-a3c5-dff81a75df02
DOI: 10.1101/2025.09.29.678898

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