Article

BoltzProt-1: Towards Efficient De Novo Binder Design with Good Developability

2026-06-27

Abstract excerpt

Designing binders against novel protein targets remains a central challenge in computational drug discovery. Here we introduce BoltzProt-1 , a pipeline for generating protein binders, including nanobodies, with improved hit rates and favorable developability properties. At its core lie a refined iteration of BoltzGen’s generative model and a novel protein-protein interaction prediction model, BoltzPPI . Employin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca59a84d-9e85-537a-8c80-a6a5f5413f09
DOI: 10.64898/2026.06.23.733997

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BoltzProt-1: Towards Efficient De Novo Binder Design with Good DevelopabilityDOI 10.64898/2026.06.23.733997Read

Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologiesSemantic proximity Read

The Human Bindome: A Proteome-scale Atlas of Designed Binder CandidatesSemantic proximity Read

Automated and modular protein binder design with BinderFlowSemantic proximity Read

Aiki-GeNano: Multi-Stage Preference Optimization for Generative Design of Developable NanobodiesSemantic proximity Read

Mapping targetable sites on the human surfaceome for the design of novel bindersSemantic proximity Read

<i>De novo</i> design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time computeSemantic proximity Read

Engineered Peptide Barcodes for In-Depth Analyses of Binding Protein EnsemblesSemantic proximity Read

<i>In silico</i> evolution of protein binders with deep learning models for structure prediction and sequence designSemantic proximity Read

BindCraft: one-shot design of functional protein bindersSemantic proximity Read

Unlocking <i>de novo</i> antibody design with generative artificial intelligenceSemantic proximity Read

EvoBind: peptide binder design with inverse folding and protein structure predictionSemantic proximity Read

De novo designed pMHC binders facilitate T cell induced killing of cancer cellsSemantic proximity Read