Article

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates

2026-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Affinity reagents such as antibodies are indispensable for interrogating proteins’ biological function. Yet they are costly and frequently unreliable, with unknown sequences, posing challenges to reproducible experimental research. Deep learning-based protein design can now in silico generate affinity reagents achieving reliable experimental success rates, but has remained largely confined to s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c11781a1-39e1-57f1-b59b-27b1a8afeaa2
DOI: 10.64898/2026.07.30.741542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Human Bindome: A Proteome-scale Atlas of Designed Binder CandidatesDOI 10.64898/2026.07.30.741542Read

Automated and modular protein binder design with BinderFlowSemantic proximity Read

BindCraft: one-shot design of functional protein bindersSemantic proximity Read

<i>In silico</i> evolution of protein binders with deep learning models for structure prediction and sequence designSemantic proximity Read

Mapping targetable sites on the human surfaceome for the design of novel bindersSemantic proximity Read

BoltzProt-1: Towards Efficient De Novo Binder Design with Good DevelopabilitySemantic proximity Read

SNAC-DB: An ML-Ready Database for Antibody and NANO-BODY® VHH–Antigen Complexes with Expanded Structural Diversity and Real-World BenchmarkingSemantic proximity Read

Engineered Peptide Barcodes for In-Depth Analyses of Binding Protein EnsemblesSemantic proximity Read

A Comprehensive Atlas and Machine-Learning Framework for Predicting IDR-Protein Binding AffinitySemantic proximity Read

EvoBind: peptide binder design with inverse folding and protein structure predictionSemantic proximity Read

Hallucinating structure-conditioned antibody libraries for target-specific bindersSemantic proximity Read

Hallucinating structure-conditioned antibody libraries for target-specific bindersSemantic proximity Read

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modificationsSemantic proximity Read