Article

Rational Design of Selective IL-2-based Activators for CAR T Cells Using AlphaFold3 and Physics-Informed Machine Learning

2026-03-12

Abstract excerpt

Recombinant human Interleukin-2 (rhIL-2, Aldesleukin) is used in immunotherapy for metastatic melanoma and renal cell carcinoma. Low-dose IL-2 has been investigated for administration after adoptive T cell transfer to enhance CAR T expansion and sustain effector function. However, systemic IL-2 can cause severe toxicities and promote expansion of regulatory T cells (Tregs). Previous attempts at mitigating cytokine...

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Literature Corpus work: 4912709b-5d57-5ea0-a9f8-26d4eaa7572c
DOI: 10.64898/2026.03.10.710391

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