Article

BindCraft: one-shot design of functional protein binders

2024-10-01

Abstract excerpt

Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an open-source and automated pipeline for de novo protein binder design with experimental success rates of 10-100%. BindCraft leverages the weights of AlphaFold2 1 to generate binders with nanomolar affini...

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Literature Corpus work: 45a97f75-27b2-5b0d-9e14-adb854816a43
DOI: 10.1101/2024.09.30.615802

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