Article

De novo protein design enables targeting of intractable oncogenic interfaces

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Protein-protein interactions (PPIs) involving oncogenic drivers remain among the most intractable targets in cancer biology due to their dynamic conformations and limited accessibility to conventional small molecules. Although antibodies and indirect inhibitors have achieved clinical success against targets such as PD-1/PD-L1 and MYC, challenges persist related to tissue penetration, intracellul...

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Literature Corpus work: 90c19275-7da5-59aa-a006-b54fa2987f6d
DOI: 10.1101/2025.10.22.683953

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