Article

RareFold: Structure Prediction and Design of Proteins with Noncanonical Amino Acids

2025-05-23

Abstract excerpt

Protein structure prediction and design have traditionally been confined to the 20 canonical amino acids. Expanding this chemical space to include non-canonical amino acids (ncAAs) is essential for engineering proteins with novel chemical and functional properties. However, existing methods are not designed to generalise across chemically diverse residue types. Here, we present RareFold, a deep learning architectu...

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Literature Corpus work: 2c5e2bcf-61dd-5925-a44c-b57db7c61038
DOI: 10.1101/2025.05.19.654846

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