Article

Robust de novo design of protein binding proteins from target structural information alone

2021-09-05

Abstract excerpt

The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge. We describe a general solution to this problem which starts with a broad exploration of the very large space of possible binding modes and interactions, and then intensifies the search in the most promising regions. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a93d4d5b-e4d1-52e0-b6b5-420db7d794bc
DOI: 10.1101/2021.09.04.459002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust de novo design of protein binding proteins from target structural information aloneDOI 10.1101/2021.09.04.459002Read

Computational design of protein-protein interactions.Semantic proximity Read

A de novo protein binding pair by computational design and directed evolution.Semantic proximity Read

Mapping targetable sites on the human surfaceome for the design of novel bindersSemantic proximity Read

BindCraft: one-shot design of functional protein bindersSemantic proximity Read

Automated selection of stabilizing mutations in designed and natural proteins.Semantic proximity Read

DisruPPI: structure-based computational redesign algorithm for protein binding disruption.Semantic proximity Read

Core-directed protein design.Semantic proximity Read

RareFold: Structure Prediction and Design of Proteins with Noncanonical Amino AcidsSemantic proximity Read

De novo design of small-molecule–induced conformational changeSemantic proximity Read

High-throughput protein binder discovery by rapid in vivo selectionSemantic proximity Read

Computer-guided Binding Mode Identification and Affinity Improvement of an LRR Protein Binder without Structure DeterminationSemantic proximity Read

Ribosome Display: A Potent Display Technology used for Selecting and Evolving Specific Binders with Desired PropertiesSemantic proximity Read