Article

A new chemical carcinogen and Western diet protocol to reliably induce advanced hepatocellular carcinoma in male and female mice

2026-03-10

Abstract excerpt

<h4>Background and Aims</h4> A combination of chemical carcinogens and Western diet have been used to induce hepatocellular carcinoma (HCC) in mice, but these models show low incidence of HCC in female mice, while mice that do develop HCC show a wide range of HCC stage development. Therefore, a more reliable mouse model that induces advanced stage HCC in both male and female mice is warranted, which will enable r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e135be5d-3868-5ca6-a5da-2e1237f1e1f3
DOI: 10.64898/2026.03.06.710198

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A new chemical carcinogen and Western diet protocol to reliably induce advanced hepatocellular carcinoma in male and female miceDOI 10.64898/2026.03.06.710198Read

Integrative genomic analysis of mouse and human hepatocellular carcinomaSemantic proximity Read

Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarksSemantic proximity Read

Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein lossSemantic proximity Read

Differential Proteomic Analysis of DEN-Induced Hepatocellular Carcinoma in Male and Female Balb/c Mice Reveals Novel Gender Specific MarkersSemantic proximity Read

Relevance of Carcinogen-Induced Preclinical Cancer ModelsSemantic proximity Read

Establishment of a longitudinally tractable mouse model of cholestatic liver injury via drinking water administration of MDASemantic proximity Read

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.Semantic proximity Read

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver diseaseSemantic proximity Read

Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9.Semantic proximity Read

Diet-induced hepatocellular carcinoma in genetically predisposed mice.Semantic proximity Read

Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.Semantic proximity Read