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Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein loss

30 Jul 2024

Abstract excerpt

BACKGROUND AND AIMS: The chemical carcinogen diethylnitrosamine (DEN) is often used to induce HCC in mice. Curiously, several labs have reported that the removal of oncoproteins from hepatocytes exacerbated DEN-induced HCC, with mechanisms unknown. This study aimed at deciphering molecular mechanisms underlying the tumor suppressive effect of oncoproteins. APPROACH AND RESULTS: We generated mutant mouse lines...

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Identifiers

PMID: 39397357
DOI: 10.1097/hep.0000000000001037

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