Article

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease

2020-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Non-alcoholic fatty liver disease (NAFLD) is a growing epidemic associated with key aspects of metabolic disease such as obesity and diabetes. The first stage of NAFLD is characterized by lipid accumulation in hepatocytes, but this can further progress into non-alcoholic steatohepatitis (NASH), fibrosis or cirrhosis, and hepatocellular carcinoma (HCC). A western diet, high in fats, sugars and ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f63519f9-5c9a-5ef8-8924-84895d6c338f
DOI: 10.1101/2020.06.05.137174

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver diseaseDOI 10.1101/2020.06.05.137174Read

A systematic analysis of rodent models implicates adipogenesis and innate immunity in pathogenesis of fatty liver diseaseSemantic proximity Read

Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)Semantic proximity Read

Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in miceSemantic proximity Read

A new dietary rat model fully recapitulates metabolic dysfunction-associated steatotic liver disease pathophysiology and mimics human disease with advanced liver fibrosis and portal hypertensionSemantic proximity Read

Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease.Semantic proximity Read

Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD.Semantic proximity Read

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.Semantic proximity Read

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.Semantic proximity Read

Integrated Ultrasound Characterization of the Diet-Induced Obesity (Dio) Model in Young Adult C57bl/6j Mice: Assessment of Cardiovascular, Renal and Hepatic ChangesSemantic proximity Read

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug targetSemantic proximity Read

Mouse models in non‐alcoholic fatty liver disease and steatohepatitis researchSemantic proximity Read

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read