Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.

World journal of gastroenterology - 28 Apr 2016

Ambade Aditya, Satishchandran Abhishek, Gyongyosi Benedek, Lowe Patrick, Szabo Gyongyi

Abstract excerpt

AIM: To establish a mouse model of alcohol-driven hepatocellular carcinoma (HCC) that develops in livers with alcoholic liver disease (ALD). METHODS: Adult C57BL/6 male mice received multiple doses of chemical carcinogen diethyl nitrosamine (DEN) followed by 7 wk of 4% Lieber-DeCarli diet. Serum alanine aminotransferase (ALT), alpha fetoprotein (AFP) and liver Cyp2e1 were assessed. Expression of F4/80, CD68 for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Fetoproteins
Share to Cytochrome P-450 CYP2E1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diethylnitrosamine

Share to Endotoxins

Share to Liver Cirrhosis, Alcoholic

Share to Liver Neoplasms, Experimental

Share to Macrophage Activation

Share to Neutrophil Infiltration

Source

Open in PubMed Open full text

Identifiers

PMID: 27122661
DOI: 10.3748/wjg.v22.i16.4091
PMCID: PMC4837428

Genes

PCNA
AFP
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease.PMID 27122661Read ↗

Hepatocellular carcinoma in the context of non-alcoholic steatohepatitis (NASH): recent advances in the pathogenic mechanisms.Semantic proximity Read ↗

A new chemical carcinogen and Western diet protocol to reliably induce advanced hepatocellular carcinoma in male and female miceSemantic proximity Read ↗

Alcohol-associated liver cancerSemantic proximity Read ↗

Past, present, and future of chemically induced hepatocarcinogenesis rodent models: Perspectives concerning classic and new cancer hallmarksSemantic proximity Read ↗

Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma.Semantic proximity Read ↗

Experimental mouse models for hepatocellular carcinoma researchSemantic proximity Read ↗

Aging promotes inflammation and steatosis in alcohol-associated liver disease in miceSemantic proximity Read ↗

Alcohol induced hepatic degeneration in a hepatitis C virus core protein transgenic mouse model.Semantic proximity Read ↗

Gene expression, regulation of DEN and HBx induced HCC mice models and comparisons of tumor, para-tumor and normal tissuesSemantic proximity Read ↗

Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing Into Liver Cirrhosis and TumorsSemantic proximity Read ↗

Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein lossSemantic proximity Read ↗

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.