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Article

Diet-induced hepatocellular carcinoma in genetically predisposed mice.

Human molecular genetics - 15 Aug 2009

Hill-Baskin Annie E, Markiewski Maciej M, Buchner David A, Shao Haifeng, DeSantis David, Hsiao Gene, Subramaniam Shankar, Berger Nathan A, Croniger Colleen, Lambris John D, Nadeau Joseph H

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide, with approximately 70% of cases resulting from hepatitis B and C viral infections, aflatoxin exposure, chronic alcohol use or genetic liver diseases. The remaining approximately 30% of cases are associated with obesity, type 2 diabetes and related metabolic diseases, although a direct link between these pathologies and HCCs has...

Topics

Animals
Carcinoma, Hepatocellular
Dietary Fats
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Liver
Liver Neoplasms
Male
Mice
Mice, Inbred A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 19454484
DOI: 10.1093/hmg/ddp236
PMCID: PMC2714725

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