Article
Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.
Toxicologic pathology - 1 Jun 2011
Hoenerhoff Mark J, Pandiri Arun R, Lahousse Stephanie A, Hong Hu-Hua, Ton Tai-Vu, Masinde Tiwanda, Auerbach Scott S, Gerrish Kevin, Bushel Pierre R, Shockley Keith R, Peddada Shyamal D, Sills Robert C
Abstract excerpt
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular pathogenesis of this disease is complex, and in general, treatment options remain poor. The use of rodent models to study human cancer has been extensively pursued, both through genetically engineered rodents and rodent models used in carcinogenicity and...
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