Article

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34 <sup>+</sup> hematopoietic progenitor cells and humanized mice

2024-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infection the virus utilizes pUL38 to limit Akt phosphorylation and activation. During latency, PI3K/Akt signaling also limits virus replication, but how this is ove...

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Literature Corpus work: e118bc28-374e-5b23-90b9-daafcfdb9432
DOI: 10.1101/2024.05.24.595672

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