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Regulation of Latency and Reactivation by Human Cytomegalovirus miRNAs

13 Feb 2021

Abstract excerpt

Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidence points to a critical role for HCMV miRNAs in mediating latency in CD34+ hematopoietic progenitor cells through modulation of cellular signaling pathways, including...

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PMID: 33668486
DOI: 10.3390/pathogens10020200

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