Article

UL135 and UL136 Epistasis Controls Reactivation of Human Cytomegalovirus

2023-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) is beta herpesvirus that persists indefinitely in the human host through a protracted, latent infection. The polycistronic UL133-UL138 gene locus of HCMV encodes genes regulating latency and reactivation. While UL138 is pro-latency, restricting virus replication in CD34+ hematopoietic progenitor cells (HPCs), UL135 overcomes this restriction for reactivation. By con...

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Literature Corpus work: e6b9d91a-16d3-5f86-bb15-a0f8d23cf913
DOI: 10.1101/2023.01.24.525282

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