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Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34+ progenitors

7 Apr 2011

Abstract excerpt

One site of latency of human cytomegalovirus (HCMV; human herpesvirus 5) is known to be CD34(+) haematopoietic progenitor cells, and it is likely that carriage of latent virus has profound effects on cellular gene expression in order to optimize latency and reactivation. As microRNAs (miRNAs) play important roles in regulating stem-cell gene expression, this study asked whether latent carriage of HCMV led to...

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PMID: 21471310
DOI: 10.1099/vir.0.031377-0

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