Article

Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins

2023-04-17

Abstract excerpt

<h4>ABSTRACT</h4> The phosphoinositide 3-kinase (PI3K)/AKT pathway plays crucial roles in cell viability and protein synthesis and is frequently co-opted by viruses to support their replication. Although many viruses maintain high levels of AKT activity during infection, other viruses, such as vesicular stomatitis virus and human cytomegalovirus (HCMV), cause AKT to accumulate in an inactive state. To efficiently...

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Literature Corpus work: 9e04e900-1dea-5add-9afc-d9e1b54710e4
DOI: 10.1101/2023.04.17.537203

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