Article

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36

2025-11-05

Abstract excerpt

Human cytomegalovirus (HCMV) establishes latency in CD34 + hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation. We demonstrate that the Notch signaling pathway, a key regulator of stem cell maintenance and differentiation, functions as a barrier to HCMV reactivation. Two viral gene products, UL8 and miR-UL36, modulate this pathway during reactivation. UL8 pro...

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Identifiers and source

Literature Corpus work: 781920aa-9d84-52e5-9382-dddf54e3540a
DOI: 10.1101/2025.11.05.686718

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