Article

The AKT Forkhead box O transcription factor axis regulates human cytomegalovirus replication

2022-04-15

Abstract excerpt

<h4>ABSTRACT</h4> The serine/threonine protein kinase AKT is a critical mediator of growth factor signaling that broadly impacts mRNA translation, metabolism, programmed cell death and stress responses. Human cytomegalovirus (HCMV), a large dsDNA virus in the herpesvirus family, dramatically remodels host cell signaling pathways during lytic infection. Here, we show that AKT accumulates in an inactive form during...

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Literature Corpus work: 6acad8cc-efa8-5316-a6b2-7448f27bee76
DOI: 10.1101/2022.04.14.488435

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