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Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 + Hematopoietic Progenitor Cells from Apoptosis

5 Jan 2021

Abstract excerpt

Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34 + hematopoietic progenitor cells (HPCs) and periodically reactivate to cause disease in the absence of an intact immune system.

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PMID: 33408225
DOI: 10.1128/msphere.00986-20

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