Article

EGR1 transcriptional control of human cytomegalovirus latency

2019-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Sustained phosphotinositide3-kinase (PI3K) signaling is critical to the maintenance of herpesvirus latency. We have previously shown that the beta-herpesvirus, human cytomegalovirus (CMV), regulates epidermal growth factor receptor (EGFR), upstream of PI3K, to control states of latency and reactivation. Inhibition of EGFR signaling enhances CMV reactivation from latency and increases viral repli...

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Literature Corpus work: 8e8bc2db-fbd0-54c7-9125-64379ac5fab0
DOI: 10.1101/648543

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